Cornell College researchers have recognized a brand new option to harness the antioxidant and antibacterial properties of a botanical compound to make nanofiber-coated cotton bandages that struggle an infection and assist wounds heal extra rapidly.
The findings are particularly necessary given the rising prevalence of multidrug-resistant micro organism.
Cotton gauze is without doubt one of the most typical wound dressings; it is cheap, available, snug and biocompatible. Nonetheless, it would not promote therapeutic or struggle an infection.
“Cotton alone can not present a solution for these problems – it must be biofunctionalized,” stated lead writer Mohsen Alishahi, a doctoral pupil in fiber science who works within the NanoFibers and NanoTextiles (NanoFibTex) Laboratory.
Tamer Uyar, affiliate professor and the lab’s director, stated considered one of its primary analysis pursuits is creating practical fibers from sustainable supplies and exploring their potential purposes in medical textiles and drug supply methods.
Researchers used lawsone, a red-orange compound present in henna leaves that has antioxidant, anti-inflammatory and antimicrobial properties, to spice up the efficiency of cotton.
The experimental dressing had glorious antibacterial efficiency in opposition to gram-negative and gram-positive bacterial species, and successfully eradicated E. coli and staph micro organism in testing.
The extended overuse of artificial antibiotics in excessive concentrations has contributed to the rise of the lethal epidemic of multidrug-resistant microbes. So using pure and potent anti-bacterials comparable to lawsone might function an alternative choice to artificial anti-bacterials.”
Tamer Uyar, Affiliate Professor, Cornell College
“Wound dressings ought to present an acceptable surroundings for facilitating therapeutic and stopping an infection,” Alishahi stated. “Utilizing completely pure supplies comparable to cotton, cyclodextrin and lawsone, this dressing can facilitate each because it has complete antioxidant and anti-bacterial exercise.”
Alishahi stated that the dressing can be significantly useful for persistent wounds which are extremely inclined to an infection, like diabetic ulcers and burns. The antioxidant and anti inflammatory properties would additionally profit extra routine wounds by lowering the formation of scars.
This analysis was funded by Cotton Included.
Alishahi, M., et al. (2024). Functionalization of cotton nonwoven with cyclodextrin/lawsone inclusion advanced nanofibrous coating for antibacterial wound dressing. Worldwide Journal of Pharmaceutics. doi.org/10.1016/j.ijpharm.2024.123815.